diff --git a/doc/Changelog b/doc/Changelog
index 97959cf26..4d35a747e 100644
--- a/doc/Changelog
+++ b/doc/Changelog
@@ -2,6 +2,8 @@
 	- Fix for python reply callback to see mesh state reply_list member,
 	  it only removes it briefly for the commpoint call so that it does
 	  not drop it and attempt to modify the reply list during reply.
+	- Fix that if there are on reply callbacks, those are called per
+	  reply and a new message created if that was modified by the call.
 
 13 October 2020: Wouter
 	- Fix #323: unbound testsuite fails on mock build in systemd-nspawn
diff --git a/services/mesh.c b/services/mesh.c
index 8f746ea8e..c22ef43fa 100644
--- a/services/mesh.c
+++ b/services/mesh.c
@@ -1235,7 +1235,7 @@ mesh_send_reply(struct mesh_state* m, int rcode, struct reply_info* rep,
 		prev->edns.bits == r->edns.bits && 
 		prev->edns.udp_size == r->edns.udp_size &&
 		edns_opt_list_compare(prev->edns.opt_list, r->edns.opt_list)
-		== 0) {
+		== 0 && !env->inplace_cb_lists[inplace_cb_reply]) {
 		/* if the previous reply is identical to this one, fix ID */
 		if(prev_buffer != r_buffer)
 			sldns_buffer_copy(r_buffer, prev_buffer);