diff --git a/acx_python.m4 b/acx_python.m4
index 2940971f1..a84daa035 100644
--- a/acx_python.m4
+++ b/acx_python.m4
@@ -58,6 +58,11 @@ $ac_distutils_result])
         AC_MSG_RESULT([$PYTHON_LDFLAGS])
         AC_SUBST([PYTHON_LDFLAGS])
 
+        if test -z "$PYTHON_LIBDIR"; then
+                PYTHON_LIBDIR=`$PYTHON -c "from distutils.sysconfig import *; \
+                        print(get_config_var('LIBDIR'));"`
+        fi
+
         #
         # Check for site packages
         #
diff --git a/configure b/configure
index 595c156b8..fb1ce374e 100755
--- a/configure
+++ b/configure
@@ -17329,6 +17329,11 @@ $as_echo_n "checking for Python library path... " >&6; }
 $as_echo "$PYTHON_LDFLAGS" >&6; }
 
 
+        if test -z "$PYTHON_LIBDIR"; then
+                PYTHON_LIBDIR=`$PYTHON -c "from distutils.sysconfig import *; \
+                        print(get_config_var('LIBDIR'));"`
+        fi
+
         #
         # Check for site packages
         #
@@ -17434,6 +17439,15 @@ $as_echo "#define HAVE_PYTHON 1" >>confdefs.h
       else
         CPPFLAGS="$PYTHON_CPPFLAGS"
       fi
+      if test "$PYTHON_LIBDIR" != "/usr/lib" -a "$PYTHON_LIBDIR" != "" -a "$PYTHON_LIBDIR" != "/usr/lib64"; then
+
+	if test "x$enable_rpath" = xyes; then
+		if echo "$PYTHON_LIBDIR" | grep "^/" >/dev/null; then
+			RUNTIME_PATH="$RUNTIME_PATH -R$PYTHON_LIBDIR"
+		fi
+	fi
+
+      fi
       ub_have_python=yes
       if test -n "$PKG_CONFIG" && \
     { { $as_echo "$as_me:${as_lineno-$LINENO}: \$PKG_CONFIG --exists --print-errors \"\"python\${PY_MAJOR_VERSION}\"\""; } >&5
diff --git a/configure.ac b/configure.ac
index e71bc5888..f96a24ef2 100644
--- a/configure.ac
+++ b/configure.ac
@@ -678,6 +678,9 @@ if test x_$ub_test_python != x_no; then
       else
         CPPFLAGS="$PYTHON_CPPFLAGS"
       fi
+      if test "$PYTHON_LIBDIR" != "/usr/lib" -a "$PYTHON_LIBDIR" != "" -a "$PYTHON_LIBDIR" != "/usr/lib64"; then
+        ACX_RUNTIME_PATH_ADD([$PYTHON_LIBDIR])
+      fi
       ub_have_python=yes
       PKG_CHECK_EXISTS(["python${PY_MAJOR_VERSION}"],
                        [PC_PY_DEPENDENCY="python${PY_MAJOR_VERSION}"],
diff --git a/doc/Changelog b/doc/Changelog
index 8125b87ea..796c587e2 100644
--- a/doc/Changelog
+++ b/doc/Changelog
@@ -1,3 +1,6 @@
+20 April 2020: Wouter
+	- Fix #222: --with-rpath, fails to rpath python lib.
+
 17 April 2020: George
 	- Add SNI support on more TLS connections (fixes #193).
 	- Add SNI support to unbound-anchor.