diff --git a/doc/src/sgml/maintenance.sgml b/doc/src/sgml/maintenance.sgml
index 356e826ff16..80f938bebbf 100644
--- a/doc/src/sgml/maintenance.sgml
+++ b/doc/src/sgml/maintenance.sgml
@@ -821,6 +821,12 @@ HINT:  Execute a database-wide VACUUM in that database.
       <simpara>Running transactions and prepared transactions can be ignored if there
        is no chance that they might appear in a multixact.</simpara>
      </listitem>
+     <listitem>
+      <simpara>Unlike transaction ID wraparound, replication slots do not
+       directly hold back multixact cleanup. Dropping stale replication
+       slots is therefore not usually relevant to resolving multixact ID
+       wraparound problems.</simpara>
+     </listitem>
      <listitem>
       <simpara>MXID information is not directly visible in system views such as
        <literal>pg_stat_activity</literal>; however, looking for old XIDs is still a good
diff --git a/src/backend/access/transam/multixact.c b/src/backend/access/transam/multixact.c
index 5067c2a3e39..9020f1448c4 100644
--- a/src/backend/access/transam/multixact.c
+++ b/src/backend/access/transam/multixact.c
@@ -1260,14 +1260,14 @@ GetNewMultiXactId(int nmembers, MultiXactOffset *offset)
 						 errmsg("database is not accepting commands that assign new MultiXactIds to avoid wraparound data loss in database \"%s\"",
 								oldest_datname),
 						 errhint("Execute a database-wide VACUUM in that database.\n"
-								 "You might also need to commit or roll back old prepared transactions, or drop stale replication slots.")));
+								 "You might also need to commit or roll back old prepared transactions.")));
 			else
 				ereport(ERROR,
 						(errcode(ERRCODE_PROGRAM_LIMIT_EXCEEDED),
 						 errmsg("database is not accepting commands that assign new MultiXactIds to avoid wraparound data loss in database with OID %u",
 								oldest_datoid),
 						 errhint("Execute a database-wide VACUUM in that database.\n"
-								 "You might also need to commit or roll back old prepared transactions, or drop stale replication slots.")));
+								 "You might also need to commit or roll back old prepared transactions.")));
 		}
 
 		/*
@@ -1291,7 +1291,7 @@ GetNewMultiXactId(int nmembers, MultiXactOffset *offset)
 									   oldest_datname,
 									   multiWrapLimit - result),
 						 errhint("Execute a database-wide VACUUM in that database.\n"
-								 "You might also need to commit or roll back old prepared transactions, or drop stale replication slots.")));
+								 "You might also need to commit or roll back old prepared transactions.")));
 			else
 				ereport(WARNING,
 						(errmsg_plural("database with OID %u must be vacuumed before %u more MultiXactId is used",
@@ -1300,7 +1300,7 @@ GetNewMultiXactId(int nmembers, MultiXactOffset *offset)
 									   oldest_datoid,
 									   multiWrapLimit - result),
 						 errhint("Execute a database-wide VACUUM in that database.\n"
-								 "You might also need to commit or roll back old prepared transactions, or drop stale replication slots.")));
+								 "You might also need to commit or roll back old prepared transactions.")));
 		}
 
 		/* Re-acquire lock and start over */
@@ -2647,7 +2647,7 @@ SetMultiXactIdLimit(MultiXactId oldest_datminmxid, Oid oldest_datoid,
 								   oldest_datname,
 								   multiWrapLimit - curMulti),
 					 errhint("To avoid MultiXactId assignment failures, execute a database-wide VACUUM in that database.\n"
-							 "You might also need to commit or roll back old prepared transactions, or drop stale replication slots.")));
+							 "You might also need to commit or roll back old prepared transactions.")));
 		else
 			ereport(WARNING,
 					(errmsg_plural("database with OID %u must be vacuumed before %u more MultiXactId is used",
@@ -2656,7 +2656,7 @@ SetMultiXactIdLimit(MultiXactId oldest_datminmxid, Oid oldest_datoid,
 								   oldest_datoid,
 								   multiWrapLimit - curMulti),
 					 errhint("To avoid MultiXactId assignment failures, execute a database-wide VACUUM in that database.\n"
-							 "You might also need to commit or roll back old prepared transactions, or drop stale replication slots.")));
+							 "You might also need to commit or roll back old prepared transactions.")));
 	}
 }
 
diff --git a/src/backend/commands/vacuum.c b/src/backend/commands/vacuum.c
index c42c8a680d3..b6c4216d428 100644
--- a/src/backend/commands/vacuum.c
+++ b/src/backend/commands/vacuum.c
@@ -1155,7 +1155,7 @@ vacuum_get_cutoffs(Relation rel, const VacuumParams *params,
 		ereport(WARNING,
 				(errmsg("cutoff for freezing multixacts is far in the past"),
 				 errhint("Close open transactions soon to avoid wraparound problems.\n"
-						 "You might also need to commit or roll back old prepared transactions, or drop stale replication slots.")));
+						 "You might also need to commit or roll back old prepared transactions.")));
 
 	/*
 	 * Determine the minimum freeze age to use: as specified by the caller, or