diff --git a/pytest.ini b/pytest.ini
index 5091f2836..92a403451 100644
--- a/pytest.ini
+++ b/pytest.ini
@@ -22,6 +22,11 @@
 #    the certbot.display.util module.
 # 5) A deprecation warning is raised in dnspython==1.15.0 in the oldest tests for
 #    certbot-dns-rfc2136.
+# 6) The vendored version of six in botocore causes ImportWarnings in Python
+#    3.10+. See https://github.com/boto/botocore/issues/2548.
+# 7) botocore's default TLS settings raise deprecation warnings in Python
+#    3.10+, but their values are sane from a security perspective. See
+#    https://github.com/boto/botocore/issues/2550.
 filterwarnings =
     error
     ignore:The external mock module:PendingDeprecationWarning
@@ -29,3 +34,5 @@ filterwarnings =
     ignore:.*attribute in certbot.interfaces module is deprecated:DeprecationWarning
     ignore:.*attribute in certbot.display.util module is deprecated:DeprecationWarning
     ignore:decodestring\(\) is a deprecated alias:DeprecationWarning:dns
+    ignore:_SixMetaPathImporter.:ImportWarning
+    ignore:ssl.PROTOCOL_TLS:DeprecationWarning:botocore