diff --git a/letsencrypt-apache/letsencrypt_apache/configurator.py b/letsencrypt-apache/letsencrypt_apache/configurator.py
index e1f53f269..a1227b0bb 100644
--- a/letsencrypt-apache/letsencrypt_apache/configurator.py
+++ b/letsencrypt-apache/letsencrypt_apache/configurator.py
@@ -307,6 +307,8 @@ class ApacheConfigurator(augeas_configurator.AugeasConfigurator):
         best_points = 0
 
         for vhost in self.vhosts:
+            if vhost.modmacro is True:
+                continue
             if target_name in vhost.get_names():
                 points = 2
             elif any(addr.get_addr() == target_name for addr in vhost.addrs):
@@ -326,12 +328,27 @@ class ApacheConfigurator(augeas_configurator.AugeasConfigurator):
         # No winners here... is there only one reasonable vhost?
         if best_candidate is None:
             # reasonable == Not all _default_ addrs
-            reasonable_vhosts = self._non_default_vhosts()
+            # remove mod_macro hosts from reasonable vhosts
+            reasonable_vhosts = self._without_modmacro(
+                self._non_default_vhosts())
             if len(reasonable_vhosts) == 1:
                 best_candidate = reasonable_vhosts[0]
 
+        if best_candidate is not None and best_candidate.modmacro is True:
+            return None
         return best_candidate
 
+    def _without_modmacro(self, vhosts):
+        """Return all non mod_macro vhosts
+
+        :param vhosts: List of VirtualHosts
+        :type vhosts: (:class:`list` of :class:`~letsencrypt_apache.obj.VirtualHost`)
+
+        :returns: List of VirtualHosts without mod_macro
+        :rtype: (:class:`list` of :class:`~letsencrypt_apache.obj.VirtualHost`)
+        """
+        return [vh for vh in vhosts if vh.modmacro == False]
+
     def _non_default_vhosts(self):
         """Return all non _default_ only vhosts."""
         return [vh for vh in self.vhosts if not all(