diff --git a/bin/named/unix/dlz_dlopen_driver.c b/bin/named/unix/dlz_dlopen_driver.c
index 8f540edb55..016b390862 100644
--- a/bin/named/unix/dlz_dlopen_driver.c
+++ b/bin/named/unix/dlz_dlopen_driver.c
@@ -257,7 +257,7 @@ dlopen_dlz_create(const char *dlzname, unsigned int argc, char *argv[],
 	/* Open the library */
 	dlopen_flags = RTLD_NOW|RTLD_GLOBAL;
 
-#ifdef RTLD_DEEPBIND
+#if defined(RTLD_DEEPBIND) && !__ADDRESS_SANITIZER__
 	/*
 	 * If RTLD_DEEPBIND is available then use it. This can avoid
 	 * issues with a module using a different version of a system
diff --git a/lib/dns/dyndb.c b/lib/dns/dyndb.c
index 932244a8db..47cb3374a3 100644
--- a/lib/dns/dyndb.c
+++ b/lib/dns/dyndb.c
@@ -133,7 +133,7 @@ load_library(isc_mem_t *mctx, const char *filename, const char *instname,
 		      instname, filename);
 
 	flags = RTLD_NOW|RTLD_LOCAL;
-#ifdef RTLD_DEEPBIND
+#if defined(RTLD_DEEPBIND) && !__ADDRESS_SANITIZER__
 	flags |= RTLD_DEEPBIND;
 #endif
 
diff --git a/lib/isc/include/isc/util.h b/lib/isc/include/isc/util.h
index c4f6da8ef1..06530d1cdc 100644
--- a/lib/isc/include/isc/util.h
+++ b/lib/isc/include/isc/util.h
@@ -206,6 +206,11 @@
 #define __has_feature(x) 0
 #endif
 
+/* GCC defines __ADDRESS_SANITIZER__, so reuse the macro for clang */
+#if __has_feature(address_sanitizer)
+#define __ADDRESS_SANITIZER__
+#endif
+
 #if __GNUC__ > 4 || (__GNUC__ == 4 && __GNUC_MINOR >= 6)
 #define STATIC_ASSERT(cond, msg) _Static_assert(cond, msg)
 #elif __has_feature(c_static_assert)
diff --git a/lib/ns/hooks.c b/lib/ns/hooks.c
index d79c29f355..c5212428f1 100644
--- a/lib/ns/hooks.c
+++ b/lib/ns/hooks.c
@@ -109,7 +109,7 @@ load_plugin(isc_mem_t *mctx, const char *modpath, ns_plugin_t **pluginp) {
 	REQUIRE(pluginp != NULL && *pluginp == NULL);
 
 	flags = RTLD_LAZY | RTLD_LOCAL;
-#ifdef RTLD_DEEPBIND
+#if defined(RTLD_DEEPBIND) && !__ADDRESS_SANITIZER__
 	flags |= RTLD_DEEPBIND;
 #endif